哪种常用药物可以使尿变绿色？丙泊酚！

2014-6-9 11:17| 发布者: xyz-cn99| 查看: 12299| 评论: 31|原作者: 论坛助手

摘要: 　　丙泊酚是我们常用的镇静剂，手术科室和ICU尤其应用广泛，但是我们可能并不知道，丙泊酚居然可以让患者的尿液变成绿色。尽管颜色看上去很恐怖，但是却不会对患者造成多大的伤害，及时停药就可以了。　　延长丙 ...

　　丙泊酚是我们常用的镇静剂，手术科室和ICU尤其应用广泛，但是我们可能并不知道，丙泊酚居然可以让患者的尿液变成绿色。尽管颜色看上去很恐怖，但是却不会对患者造成多大的伤害，及时停药就可以了。
　　延长丙泊酚注射后尿液变成深绿色：一个病例报告（Dark green discoloration of the urine after prolonged propofol infusion: a case report）
　　目的：一种常用的镇静剂丙泊酚被报道使尿液变成绿色，这种情况很少见。然而，先前的报告中不确定这种颜色的变化是否存在剂量依赖性。我们报告了1例患者在延长丙泊酚输注用于治疗顽固性癫痫后，尿液变为暗绿色。
　　病例摘要：患者尿液颜色的程度依赖于丙泊酚的输注速率。减缓丙泊酚的输注速度可减轻尿液的颜色，并最终恢复正常。
　　新的观点和结论：丙泊酚输注可导致尿液变成绿色，存在剂量依赖性。正如我们的患者的情况一样，它通常是良性和可逆的。（J Clin Pharm Ther 36(6): 734-736.）
　　A 40-year-old man was admitted to the intensive care unit for loss of consciousness related to post-traumatic extradural hematoma, which was evacuated. The postoperative course was complicated by delayed weaning from mechanical ventilation because of respiratory infection and disorder of consciousness. On day 4 of admission, the patient’s urine became green in colour. His medications up to this point included propofol, sufentanil, and amoxicillin. After stopping the propofol infusion, the urine discolouration cleared within 24 h. Green discolouration of the urine is a well known side-eff ect of propofol administration. It most likely occurs as a result of a phenolic green chromophore which is conjugated in the liver and excreted in the urine. Other causes of green/blue urine include: Hartnup disease; biliverdin; pyocyanin pigment from pseudomonas urinary tract infection; and ingested substances (including cimetidine, methylene blue, amitriptyline, indometacin, and food colouring).Propofol is a commonly used intravenous anaesthetic; therefore, it is worth remembering this benign and reversible—yet alarming in appearance—side-effect to avoid distress among patients and clinicians or unnecessary expensive analysis.

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