每周论文更新----21 Oct 2016

zhouxuelong0258

每周论文更新----21 Oct 2016

周伯通博士

本周推送三篇文章，分别来自Nature Neuroscience、Nature Communications和Cell Reports杂志。文章的题目分别为："TRPA1 mediates sensation ofthe rate of temperature change in Drosophila larvae"、“Glucocorticoidregulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia"和“HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia”。

第一篇

TRPA1 mediates sensation ofthe rate of temperature change in Drosophila larvae

TRPA1介导果蝇幼虫感觉环境温度的快慢变化

Luo J, Shen WL, Montell C

Nat Neurosci. 2016 Oct 17

PMID: 27749829

Abstract

Avoidance of noxious ambient heat is crucialfor survival. A well-known phenomenon is that animals are sensitive tothe rate of temperature change. However, the cellular andmolecular underpinnings through which animals sense and respond much morevigorously to fast temperature changes are unknown.Using Drosophila larvae, we found that nociceptive rolling behaviorwas triggered at lower temperatures and at higher frequencies whenthe temperature increased rapidly. We identified neurons in the brainthat were sensitive to the speed of the temperature increase ratherthan just to the absolute temperature. These cellular and behavioralresponses depended on the TRPA1 channel, whose activity responded tothe rate of temperature increase. We proposethat larvae use low-threshold sensors in the brain to monitorrapid temperature increases as a protective alert signal to triggerrolling behaviors, allowing fast escape before the temperature of thebrain rises to dangerous levels.

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