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13. The most common location of the dorsal root ganglion is背根神经节最常见的位置是
(A) medial to the pedicle within the lateral recess 侧隐窝内 椎弓根的内侧
(B) inferolateral to the pedicle 椎弓根的外下方
(C) lateral to the superior articular facet of the corresponding vertebra 相应椎体上关节面的外侧
(D) directly below the pedicle 椎弓根的正下方
(E) medial to the superior articular facet of the corresponding vertebra 相应椎体的上关节面内侧
13. (D) In approximately 90% of cases the DRG lies in the middle zone of the intervertebral foramen, directly below the pedicle. In approximately, 8% of cases it is inferolateral and in 2% of cases it is medial to the pedicle. The center of the DRG lies over the lateral portion of the intervertebral disc in some cases. Its size increases from L1 to S1 and then progressively decreases till S4. The DRG at S1 is 6 mm in width.
The DRG contains multiple sensory cell bodies. It is the site for production of neuropeptides: substance P, enkephalin, VIP (vasoactive intestinal peptides), and other neuropeptides.
The DRG is a primary source of pain when it undergoes mechanical deformity as by an osteophyte, HNP, or stenosis. It also produces pain when it undergoes an inflammatory process either by infection or chemical irritation from a herniated nucleus pulposus, release of local neuropeptides or local vascular compromise. 约90%的病例中背根神经节位于椎间孔的中间,椎弓根的正下方。约8%的病例在椎弓根的外下方,2%在内侧。个别病DRG的中心位于椎间盘外侧部分。其大小从L1到S1逐渐加大,然后逐渐变小至S4.S1的DGR有6mm宽。
DGR包含多个感觉神经细胞体。在此处合成神经肽:P物质、脑啡呔、VIP(血管活性肠肽)和其它神经肽。当DGR受骨赘、髓核突出、椎管狭窄压迫变形时,它是引起疼痛的来源。当感染、髓核突出物刺激、局部神经肽释放、血管受损引发化学刺激导致炎症时,也会产生疼痛。
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