咪唑安定具有苯二氮卓类所共有的抗焦虑、催眠、抗惊厥、肌松和顺行性遗忘等作用,由于其消除半衰期短(0.7小时)和清除率高(100ml/min)故其可控性,目前已广泛用于临床。靶控输注是以药代动力学药效学为基础,通过调节目标药物浓度来控制麻醉深度的方法,临床应用可显示预期血药浓度。已证实咪唑安定靶控输注用于镇静时血药浓度与脑电双频指数(BIS)评分的相关性好{1}。腰+硬麻醉下用咪唑安定给以预定血药浓度观察BIS值判定患者镇静程度,从而判定辅助用药的临床效果。
Midazolam with benzene two nitrogen Zhuo class common anxiolytic, hypnotic, anticonvulsant, muscle relaxant and anterograde amnesia effect, because it has a short elimination half-life (0.7 h) and clearance rate (100ml/min) so the controllability, has been widely used in clinical. Target controlled infusion with pharmacokinetic pharmacodynamic basis, to control the depth of anesthesia by adjusting the target drug concentration, clinical application can display the target plasma concentration. Has confirmed the target controlled infusion of midazolam for sedation of serum drug concentration and bispectral index (BIS) score correlated well {1}. Give a predetermined plasma concentrations observed BIS values to determine the degree of sedation with midazolam waist + epidural anesthesia, to determine the clinical effect of adjuvant. |