in general, it depends, pt's medical conditions, nature of surgery, and pt's tolerance during the procedure, availability of blood, etc.
if patient is health, procedure is simple and no more on going bleeding, then 800 blood can be substituted by fluids without transfusion. normally, if pt can tolerate, give either LR or Saline 3 times of blood lost. but for major cardiopulmonary disorder, pt has on going bleeding and pt showing the signs of poor tolerance for acute blood lost and HB is less than 6 or 7. then transfusion is necessary.
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