PA：单次输注羟乙基淀粉或明胶并不影响幼猪肾功能

南粤麻医

该研究观察幼猪单次输注HES、明胶或平衡液20ml/kg，结果发现输注7d后肾功能并无显著差异。

Paediatr Anaesth. 2014 Sep;24(9):974-9. doi: 10.1111/pan.12445. Epub 2014 Jun 10.

Impact of 6% hydroxyethyl starch 130/0.42 and 4% gelatin on renal function in a pediatric animal model.

Witt L1, Glage S, Schulz K, Lichtinghagen R, Simann A, Pape L, Sümpelmann R.

Author information

Abstract

OBJECTIVES:

Artificial colloids, frequently used to prevent hemorrhagic shock in children, may induce serious renal side effects in critically ill adult patients. The impact of perioperative colloid infusion on the renal function in adults and children remains unclear.

AIM:

To determine the impact of single doses of artificial colloids on renal function tests, we conducted an experimental animal study. We hypothesized that neither the infusion of moderate doses of 6% hydroxyethyl starch (HES) nor of 4% gelatin (GEL) would have a serious impact on the renal function of healthy piglets.

METHODS:

Fifteen sedated piglets were randomly assigned to receive an infusion of either 20 ml·kg(-1) HES or GEL or a balanced electrolyte solution (BS, control group) over 30 min. Before and 7 days after infusion, serum and urine renal function tests were recorded and renal biopsies were taken.

RESULTS:

Serum and urine renal function tests (e.g., creatinine, urea, cystatin C, and neutrophil gelatinase-associated lipocalin) were within normal ranges, and a microscopic examination of the renal tissue in all groups revealed no major alterations such as tubular necrosis, interstitial bleeding, interstitial inflammation, or vacuoles.

CONCLUSIONS:

In this pediatric animal model, the infusion of moderate doses of artificial colloids was not found to have any relevant impact on renal function. Further clinical investigations are necessary to provide a conclusive assessment of the risk for renal impairment after HES and GEL administration during major pediatric surgery.

© 2014 John Wiley & Sons Ltd.

KEYWORDS: colloids; gelatin; hydroxyethyl starch; i.v. infusions; pediatric anesthesia; renal function; renal parameters

PMID: 24916275

http://www.ncbi.nlm.nih.gov/pubmed/24916275?dopt=Abstract