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本帖最后由 shenxiu2 于 2011-4-7 17:47 编辑
No Sex Differences in Memory Formation during General Anesthesia.
全身麻醉时记忆的形成没有性别差异
Anesthesiology. 105(5):920-926, November 2006.
Background: Women respond differently to anesthesia than men, initially recovering more rapidly, but having more postoperative morbidity. Studies on surgical patients report evidence of memory formation during anesthesia. However, sex differences in memory formation have not been explored. Therefore, the authors investigated sex differences in the implicit and explicit memory formation during general anesthesia.
背景:女性对麻醉的反应有别于男性,她们开始恢复得较快,但术后却有较多的发病率。在外科手术患者中的研究提供了麻醉时记忆形成的证据。然而,记忆形成的性别差异尚未探究。因此,笔者研究了在全身麻醉时内隐记忆和外显记忆形成的性别差异。
Methods: With ethics committee approval, 120 consenting adult patients scheduled to undergo surgery during general anesthesia were recruited. Intraoperatively, 16 target words were presented to patients via headphones, and the Bispectral Index was recorded. Postoperatively, memory for presented words was tested using a word stem completion test. The test was divided into inclusion and exclusion parts, to delineate implicit and explicit memory contributions.
方法:得到伦理委员会的批准,选择了120位知情同意及预备在全身麻醉下接受外科手术的成年患者。手术当中,通过耳机对患者讲述16个目标文字,同时记录BIS指数。术后使用一个词干补笔测验对讲述的文字进行记忆测试。这个测验分为包含测验和排除测验来反映内隐记忆和外显记忆的作用。
Results: Target and distracter hit rates were similar in men and women. For the whole study group, there was a significant difference between inclusion target hit rate (0.42) and base hit rate (0.39) (P = 0.01). Buchner's model suggested that this memory formation was attributable to both implicit and explicit memory. A Bispectral Index value greater than 50 was the only significant predictor of inclusion target hit rate. None of the patients were able to consciously recall the words presented during surgery.
结果:目标和分散击中率在男性和女性中是相似的。在整个研究组中,包含目标击中率(0.42)和基础击中率(0.39)(P)0.01)之间有显著差异。Buchner模型显示记忆的形成与内隐和外显记忆均有关。BIS值大于50仅是包含目标击中率的一个显著预测。没有病人能有意识地回忆起术中讲述的文字。
Conclusions: Patients showed greater memory performance for words presented during general anesthesia than for words not presented. However, sex differences in memory formation were not observed. A relation between hypnotic state and memory during sevoflurane anesthesia was also established, suggesting that memory formation is possible even at hypnotic depths considered to be adequate anesthesia.
结论:患者对于在全身麻醉时讲述过的文字相比未讲述过的显示更好的记忆。然而,没有发现记忆形成的性别差异。同时也确定了七氟醚麻醉时催眠状态和记忆的关系,显示甚至可能在认为是适度麻醉深度的催眠状态下都有记忆的形成。
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