1. Aim
This review is focused on acute injury and cardioprotection. Acute cardiac ischemia/reperfusion injury is due to cardiac dysfunction and cell death (apoptosis, autophagy and necrosis), but does not include the inflammatory response, which follows necrosis. Acute cardioprotection is mainly mediated by activation of signaling pathways and post-translational modification of proteins. In particular, this review focuses on two well-defined mechanisms of cardioprotection, namely preconditioning and postconditioning.
1. 目标
本文聚焦于急性损伤和心肌保护。急性心肌缺血/再灌注损伤是由于心功能不全和细胞的死亡(凋亡,自噬和坏死),但不包括因坏死后的炎性反应。急性心肌保护主要是通过激活细胞信号传导通路和翻译后修饰的蛋白质调节的。在特殊情况下,本文针对两个定义心保护机制,即预处理的和后处理。 |