Abstract: Dexmedetom idine is a novel and highly selective a
2
-adre2
nocep to r agonist.Dexmedetom idine offers beneficial pharmacological
p roperties,p roviding do se-dependent sedation,analgesia,sympatholys2
is and w ithout relevant resp iratory dep ression.Dexmedetom idine was ap
2
p roved for sedation in the intensive care unit in the USA in 1999.The
‘off-label’use of dexmedetomidine during the perioperative period has
p roved that it can attenuate hemodynam ic responses to anesthesia and
surgery,decrease sympathetic tone,reduce anesthetic and op ioid re2
quirem ents and p revent po stanesthetic shivering.This review aim s to
p resent and discuss the pharmacological p roperties and perioperative use
of dexmedetom idine.
摘要: 右美托咪啶为新型高选择性α
2
肾上腺素能受体激动剂,它具有剂量
依赖性的镇静催眠作用,还具有镇痛、抑制交感活性、无呼吸抑制等药理性
质。1999年美国FDA批准将其用于重症监护病房的镇静。在围术期“规定
范围之外”的应用表明,右美托咪啶还具有稳定血流动力学、抑制应激反应、
减少麻醉剂及阿片类药物的用量和抗寒颤等作用。本文对右美托咪啶的药
理学性质以及围术期临床应用进展进行介绍。
中国临床药理学杂志
第23卷第6期2007年11月(总第110期) |